Matrix Gla protein (MGP) and bone morphogenetic protein-2 in aortic calcified lesions of aging rats
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چکیده
منابع مشابه
Evaluation of gene expression pattern of matrix gla protein and Bone gla protein as skeletogenesis markers in Persian sturgeon (Acipenser persicus Bordin, 1897)
Bone gla protein and matrix gla protein are of common origin with evolutionary relation and have similar structural features and are functional in the formation of skeletal structures The present study have been evaluated the genes encoding vitamin k-dependant proteins (VKDPs) expression at hatching time (0), 1, 3, 6, 10, 12,14, 20, 30 and 50 in skeletal Persian sturgeon sturgeon (Acipenser per...
متن کاملHeat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.
RATIONALE Matrix Gla protein (MGP) is a calcification inhibitor, which binds and inhibits bone morphogenetic protein (BMP)-2 and -4. OBJECTIVE The objective was to determine whether MGP also binds other proteins, which could interfere with its function. METHODS AND RESULTS We transfected bovine aortic endothelial cells with N-terminally FLAG-tagged MGP and used immunoprecipitation and liqui...
متن کاملPurification of matrix Gla protein from a marine teleost fish, Argyrosomus regius: calcified cartilage and not bone as the primary site of MGP accumulation in fish.
Matrix Gla protein (MGP) belongs to the family of vitamin K-dependent, Gla-containing proteins, and in mammals, birds, and Xenopus, its mRNA was previously detected in extracts of bone, cartilage, and soft tissues (mainly heart and kidney), whereas the protein was found to accumulate mainly in bone. However, at that time, it was not evaluated if this accumulation originated from protein synthes...
متن کاملSp proteins and Runx2 mediate regulation of matrix gla protein (MGP) expression by parathyroid hormone.
As part of its catabolic action in bone, parathyroid hormone (PTH) inhibits extracellular matrix mineralization. We previously showed that PTH dose-dependently induces matrix gla protein (MGP) expression in osteoblasts and this induction is at least partially responsible for PTH-mediated inhibition of mineralization. Recently, we identified PKA and ERK/MAPK as the key signaling pathways involve...
متن کاملScoring of Matrix Gla protein (MGP) promoter variants within predicted transcription elements
Background: Matrix Gla protein (MGP) is known as a calcium scavenger within sub-endothelial space of vessels, so that its function is suggested to reduce the risk of coronary artery diseases. In this study, we predicted the role of MGP promoter rs1800801, rs1800802 and rs1800799 variants on the score changes of predicted transcription elements. Methods: The gene promoter fragments flanking the ...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2003
ISSN: 1538-7933,1538-7836
DOI: 10.1046/j.1538-7836.2003.00023.x